IN VIVO PHARMACOLOGY
ToxiPharm provides an array of preclinical pharmacology services customized to meet sponsors’ needs in their early stage preclinical pharmacology and efficacy investigations. Through its network, ToxiPharm provides an array of In Vivo Pharmacology services directed by experts in the field:
Cardiovascular models
- Myocardial ischemia reperfusion model
- Heart Failure
- Hypertension
Pulmonary Arterial Hypertension model (PAH)
- Monocrotaline-induced
- Hypoxia-induced
- Sugen/hypoxia-induced
- Acute PAH (hypoxia)
Thrombosis model
- Venous stasis (Wessler model)
o IVIG
o Thrombolitic
o Thrombogenesis
Bleeding test
- Tail time assay
- Rabbit ear bleeding model
Respiratory diseases
- Cough study (whole body plethysmograph)
- Bronchospasm (anesthetized)
- PenH analysis
- COPD model
Ischemia-reperfusion Renal
- Acute Kidney Injury (AKI)
Preclinical Imaging Platform
- Radiochemistry service that offers biomolecule labelling with different radiotracers. Measurement of the in vitro and in vivo stability of radiopharmaceuticals including biodistribution studies.
- Preclinical and clinical imaging (PET, SPECT, CT, MRI and optical imaging).
- Monitoring of cardiac function and metabolism by PET/CT/MRI. Cerebral imaging. Therapeutic monitoring in murine and xenograft cancer models. Imaging assessments of new drugs.
- Pharmacokinetics analysis and image processing service using an image analysis and visualization platform.
- Animal facilities for housing small- and medium-sized animals on location.
- Instrumentation and engineering component that works on developing new scanners and medical devices.